BMS 754807 |cas 1001350-96-4, |DC Chemicals|Supplier|Price|Buy...

来自 : 新浪博客 发布时间：2021-03-25

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DCChemicalsSupply:BMS 754807,cas1001350-96-4,, Cat No. DC3126, In stockContact: website:www.dcchemicals.com,sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,Tel: +86-21-61454686;Fax:+86-21-61642636；Product name: BMS754807, Synonym: BMS-754807,BMS 754807, Cat No. DC3126, Cas:1001350-96-4,, ChemicalName:(S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide,Molecular Formula: C23H24FN9O, MW: 461.49BMS754807 Cas#1001350-96-4,.Purity: 98%.Best Price andQuality in the Market!Supplied by DC Chemicals! BMS-754807 is apotent and reversible inhibitor of IGF-1R/IR family kinases,inhibits IGF-1R, IR, Met, TrkA and TrkB with IC50 of 1.8 nM, 1.7nM, 5.6 nM, 7.4 nM and 4.1 nM, respectively.BMS-754807 is an orally bioavailable antagonist of humaninsulin-like growth factor type I receptor (IGF-1R) with potentialantineoplastic activity. IGF-1R antagonist BMS-7548077 binds toIGF-1R, preventing IGF-1 ligand binding and activation ofIGF-1R-mediated signaling pathways; inhibition of IGF-1R-mediatedsignaling pathways may result in the inhibition of tumor cellproliferation and the induction of tumor cell apoptosis. IGF-1R isa receptor tyrosine kinase expressed on most tumor cells and isinvolved in mitogenesis, angiogenesis, and tumor cell survival.Check for active clinical trials or closed clinical trials usingthis agent. (NCI Thesaurus)For the detailed information about the solubility of BMS754807 in water, the solubility of BMS 754807 in DMSO, thesolubility of BMS 754807 in PBS buffer, the animal experiment ofBMS 754807,the in vivo and in vitro test of BMS 754807,the cellexperiment of BMS 754807,the IC50 and EC50 of BMS 754807pleasecontact DC Chemicals.